Definitely! DH and I have been on several without DD; DM and I have done one or two as well-her 70th will be celebrated on a quick 4 day cruisel, and DM, DF, DH and I did a European without DD. We love the ships (so elegant), the service and the Disney music in the hallways. DH and DF enjoy the Broadway-style shows, I enjoy the Rainforest Room, and DM says her "happy place" is
Castaway Cay. It IS more expensive, cannot lie, but I've always felt they were worth it---and I've been sick for 2 of mine
Fortunately, Port C is a good 7 1/2 hour drive away or DH would be hearing "hey, guess what we're doing this weekend" a lot.
As WDW and DL move away from anything resembling a vacation for me,
DCL receives much more of my vacation dollar.