Comedy - Friends
Comedy, Honorable Mentions - The Office, Mad About You, and, more recently, The Middle
Drama - LOST
Drama, Honorable Mentions - 24, The 100
Guilty Pleasure - Grey's Anatomy - I can't quit with this show.
And I have to mention "Black Sails" which would actually probably be my very favorite show, but (1) there are just 4 seasons & (2), since it was a STARZ show, I don't think it has the universal appeal that a show like LOST has. However, I absolutely loved it & became slightly obsessed w/ it while DH & I were binge-watching it. "Black Sails" was so superbly acted, & many of the lines were down-right literary in their exquisite-ness & execution. Toby Stephens, as Captain Flint, was mesmerizing. And I am in love w/ the pirate Charles Vane.
Shows like "LOST," "The 100," & "Black Sails" have so many different layers & nuances & interesting characters & "talking points"... Essays could be written on some of the characters & themes presented.