My dad never reacts to vaccines. But he reacted pretty strongly to both shingles shots. Fever, extreme fatigue, chills, overall flulike symptoms. If he HAD to be somewhere, he could have done it, but he wouldn't have been much good for anything. He also reacted to the three-shot combination he got recently: RSV, high-dose flu, and Covid booster. We're guessing it was the RSV, since he got the other two together just fine last year.
My general rule of thumb for any vaccine I haven't had before: Do it right before the weekend. If you don't react, great! But if you do, you have time to recover.