We did Thanksgiving at Disney in 2007. DH and our 4 kids and my brother, his wife and son. Had a great time.
Just DH, DD and I went to her soccer showcase at Disney in 2017 with just one day at EPCOT. REALLY missed Thanksgiving at home and my 3 sons who were not able to join us. Will never intentionally leave them to fend for themselves on a major holiday again. Just bothered me that our at the time 18 and 19 year old sons went to DH's step mother's sister's for Thanksgiving Dinner instead of having immediate family to celebrate with.
And I am the one who now hosts 20 plus people at our house for Thanksgiving and Christmas, so if I am not here to host, we all miss out on that big family tradition.
Easter-I work at our church. Easter is one of our busiest weeks and I have never been able to get out of the office at all for it. The kid's spring break was always the week before Easter and for their spring break, they got to go to a lot of church-not really fair, but it is what it is.
As my kids get older with their own careers and families, DH and I would consider traveling for the holidays, if I am not hosting a big crowd. Just have to see how life plays out.