Across the values and even the moderates there's a big feeling of "ask for a top floor because it's quieter" - i.e., you won't have any noise coming from above. Which is technically true. I've stayed in on-site resorts on the top floor and on the ground floor and I've never experienced any great amount of noise in either case.
I like requesting "ground floor, near transportation" for the sake of being able to get up and go quickly in the AM without having to deal with stairs or elevators. But the Nemo suites are closest to the main hall/transportation anyway. you really can't go wrong wherever they end up sticking you there.