We just flew in and out of Tampa last week for Thanksgiving as the prices were a fraction of the cost of Orlando. I would rent a car, it is super easy and convenient. We flew in/out on Saturdays so there was no real traffic in Tampa and it is an easy drive. Basically you get on I-4 to Disney.
The airport is much smaller too. So the extra driving time will more than likely be made up by the time savings at ticketing, security, etc.