The last few times I've gone to so. cal, I've flown into Las Vegas and driven in.
We like to stay at the border, in Jean or Primm, NV. They have a group of hotels there, Whiskey Pete's, Buffalo Bills, and Primm Valley Resort and Casino. It's only about an hour out of Vegas, but it tends to be so much cheaper. And, one hour of the drive is under your belts the next morning. For us, with about a 45 minute stop for lunch and one bathroom break, it took us about 4.5 hours from Primm to our hotel on Harbor. A word of caution, though, going IN to LA on Sunday and going OUT of LA on Friday are both pure hell. Avoid it at all costs, if you can. It will honestly add about 2 hours (or more) to your trip.
As far as things to see, others may be able to help you here, but there isn't anything I can think of other than the outlet malls along the way.