I don't know what road you're using, so hopefully this will help.
We love using a book called Drive I-95. It's got a ton of information of everything on the way, has highly detailed maps of the route and outlines all of the hotels, restaurants, gas stations etc at each exit plus shows every rest stop along the way. We use it to mark hotels and restaurants that we've used at their exits just to get a sense of each trip, remember what we liked, etc. Did you know that the mile markers count down on the way to Florida, so when you see Exit 50, that means 50 miles to the end of the state. The book told us!
We like bringing hard boiled eggs and cheese sticks for quick protein snacks, nuts, M&Ms, pop tarts, granola bars. DH and I usually don't like to eat full meals on the road, we just plan on one restaurant stop on the way, either a late lunch or dinner when we stop for the night. For the kids, we'll grab something at a drive-through. At rest stops, we make sure everyone gets fresh snacks and drinks so we don't have to do it while driving.
We have lots of paper bowls and a lap tray for each kid to put their food on.
Make sure you have some sort of roadside assistance, either AAA or through your auto insurance so you have someone to call right away if anything goes wrong.
EZ Pass for everything until Florida, then you can pick up a SunPass at the Florida Welcome Center, or have a couple rolls of quarters so you can go through toll booths without having to stop and give the money. We love using 417 instead of I-4 through Orlando. You get off I-4 at Sanford and it takes you all the way to WDW. There are 6-7 toll booths along the way. Just don't listen to your GPS/Maps when you get on there. It will constantly try to get you to exit and get back to I-4. Just know that once you're on 417, you can turn onto International Drive or straight to World Drive at Disney - you'll never have to turn before that.
We plan on no more than 3 hours each driving shift.
Have you looked at the "For 2000 miles+ drivers" thread? It's got a ton of information and still the nicest thread on the DISboards! No one gets annoyed if you ask the same question that's been asked a hundred times before. The people there welcome new drivers, we're kinda proud of our status as non-flyers lol. So always willing to help with whatever questions you have.