We used to not have to, but it's gotten to the point where yes, we do laundry on vacation.
Other than the wonderfulness of going home with clean laundry, the stink factor
alone is enough for anybody to want to do laundry on vacation.
I'm sorry, but my DH & DS's are the worst about leaving their clothes all turned and twisted when talking them off. There is no way I'm sticking my hand inside of some radio-active 10 day old socks to wait and wash them when we get home.
Our last family trip was 10 days and I'm pretty sure i did laundry 3x.
I never had a problem, it didn't seem like OMGosh, here I am, off to schlep the laundry.
Now when I took my Girl Scout troop on our trip this past June. Heck yeah we did laundry, we had DVC, and we did laundry every single day. It was so easy at the end of the day to pop everybodys sweaty smelly, stinky clothes in for a wash. I did find that the driers in the DVC (stackables) took f o r e v a h to dry any kind of thick material. Jean shorts, thick khaki type shirts. We found it best to hang them up to dry, then in the morning we'd pop them in the dryer for 5 mins to de-wrinkle them all.